Our Publications
Gurney, ME, et al. Design and synthesis of selective phosphodiesterase 4D (PDE4D) allosteric inhibitors for the treatment of Fragile X Syndrome and other brain disorders. J Med Chem. 2019 May
Dogra, D.: Kcna1a mutant zebrafish model episodic ataxia type 1 (EA1) with epilepsy and show response to first-line therapy carbamazepine. Epilepsia 2018 Mar
Hagen, TJ. : Discovery of triazines as selective PDE4B versus PDE4D inhibitors. Biorg & Med Chem. Dogra, D., Epilepsia 2018 Mar
Dalby, A, et al. A concise synthesis of biaryl PDE4D allosteric modulators. Tetrahedron Lett. 2013
Burgin, AB, et al. Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat Biotechnol. 2010 Jan
Kinch, CD, et al. Selective allosteric inhibition of phosphodiesterase 4B (PDE4B) as a potential anti-seizure treatment for Dravet Syndrome. American Epilepsy Society 2024 Dec